| Matchup | Time (ET) | TV Network |
|---|---|---|
| Tuesday, October 14, 2025 | ||
| New Mexico State Liberty | 7:00pm | CBSSN |
| Arkansas State South Alabama | 7:30pm | ESPN2 |
| FIU Western Kentucky | 8:00pm | ESPNU |
| Wednesday, October 15, 2025 | ||
| Delaware Jacksonville State | 7:00pm | ESPN2 |
| UTEP Sam Houston | 7:00pm | CBSSN |
| Thursday, October 16, 2025 | ||
| Tulsa East Carolina | 7:30pm | ESPN |
| Friday, October 17, 2025 | ||
| Louisville #2 Miami (FL) | 7:00pm | ESPN |
| #25 Nebraska Minnesota | 8:00pm | FOX |
| San Jose State Utah State | 9:00pm | CBSSN |
| North Carolina California | 10:30pm | ESPN |
| Saturday, October 18, 2025 | ||
| #10 LSU #17 Vanderbilt | 12:00pm | ABC/ESPN3 |
| #12 Georgia Tech Duke | 12:00pm | ESPN |
| Baylor TCU | 12:00pm | ESPN2 |
| Washington Michigan | 12:00pm | FOX |
| Arizona Houston | 12:00pm | FS1 |
| UConn Boston College | 12:00pm | ACCN |
| Central Michigan Bowling Green | 12:00pm | CBSSN |
| Army Tulane | 12:00pm | ESPNU |
| Eastern Michigan Miami (OH) | 12:00pm | ESPN+ |
| #14 Oklahoma South Carolina | 12:45pm | SECN |
| West Virginia UCF | 1:00pm | TNT/HBO Max |
| Kent State Toledo | 2:00pm | ESPN+ |
| Buffalo UMass | 2:30pm | ESPN+ |
| Purdue Northwestern | 3:00pm | BTN |
| Troy ULM | 3:00pm | ESPN+ |
| #5 Ole Miss #9 Georgia | 3:30pm | ABC/ESPN3 |
| #4 Texas A&M Arkansas | 3:30pm | ESPN |
| #1 Ohio State Wisconsin | 3:30pm | CBS/Paramount+ |
| Michigan State #3 Indiana | 3:30pm | Peacock |
| SMU Clemson | 3:30pm | ACCN |
| UTSA North Texas | 3:30pm | ESPN+ |
| Wyoming Air Force | 3:30pm | CBSSN |
| Northern Illinois Ohio | 3:30pm | ESPN+ |
| UNLV Boise State | 3:30pm | FS1 |
| Temple Charlotte | 3:30pm | ESPN+ |
| Coastal Carolina App State | 3:30pm | ESPN+ |
| Old Dominion James Madison | 3:30pm | ESPNU |
| Akron Ball State | 3:30pm | ESPN+ |
| Texas State Marshall | 3:30pm | ESPN+ |
| #7 Texas Tech Arizona State | 4:00pm | FOX |
| #22 Memphis UAB | 4:00pm | ESPN2 |
| Mississippi State Florida | 4:15pm | SECN |
| Southern Miss Louisiana | 5:00pm | ESPN+ |
| #8 Oregon Rutgers | 6:30pm | BTN |
| Washington State #18 Virginia | 6:30pm | The CW |
| #21 Texas Kentucky | 7:00pm | ESPN |
| Maryland UCLA | 7:00pm | FS1 |
| Penn State Iowa | 7:00pm | Peacock |
| Georgia State Georgia Southern | 7:00pm | ESPN+ |
| Hawaii Colorado State | 7:00pm | Spectrum/MWN |
| #20 USC #13 Notre Dame | 7:30pm | NBC/Peacock |
| #11 Tennessee #6 Alabama | 7:30pm | ABC/ESPN3 |
| Florida Atlantic #19 South Florida | 7:30pm | ESPNU |
| Pitt Syracuse | 7:30pm | ACCN |
| #16 Missouri Auburn | 7:45pm | SECN |
| #23 Utah #15 BYU | 8:00pm | FOX |
| #24 Cincinnati Oklahoma State | 8:00pm | ESPN2 |
| Nevada New Mexico | 9:45pm | FS1 |
| Lafayette Oregon State | 10:00pm | The CW |
| Florida State Stanford | 10:30pm | ESPN |